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Metformin also regulates the expression of certain miRNAs and CSC-specific genes (), but it is unclear which if any of these are direct targets.

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Changes in weight and leisure physical activity in all three groups and adherence to the medication regimen in the metformin and placebo groups are shown in Participants assigned to the lifestyle intervention had much greater weight loss and a greater increase in leisure physical activity than did participants assigned to receive metformin or placebo.

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